Very interesting. When I was in process of being diagnosed my physician prescribed that I eat a steak at least once a week. He then put me on the injections, which had a remarkable and quick effect. Later he replaced the injections with daily sublingual 250 mcg, which seem to work fine as long as I let the pastilles dissolve up and I don't chew them. The problem is absorption in the gut, not direct absorption into the bloodstream. 250mcg daily looks like an awful lot, but even sublingual absorption is relatively low, so it has to be regular.